THE NICHOLAS CONOR INSTITUTE Curing Kids Cancer Through Collaboration
In the US, cancer is the leading cause of death by disease among children between infancy and 15 years
About 11,000 children and more than 70,000 adolescents and young adults are estimated to have been diagnosed with cancer in 2009
One in four survivors are expected to die from recurrences of the original cancer or from non-cancer-related causes such as heart and respiratory
Leukemia, brain and other central nervous system tumors account for over half of the cancers diagnosed
Recent reports indicates that incidences of leukemia and brain cancer are on the rise in the younger populations.
Despite improvements in five-year survival rates to between 75% and 80%, there continue to be myriad adverse events attributed to the current therapies provided
Life threatening health issues are correlated to the toxic treatment regimens given to children when they were young
Only about 25% of the survivors remain healthy, while the other 75% fall prey to second cancers, strokes, bone marrow depression, lung damage, weakened heart muscles, congestive heart failure, hearing loss, respiratory disorders, and even obesity
Children who survive cancer therapies live, on an average, ten years less than the general population. For all types of pediatric cancers, decrease in life expectancy ranges from 4 (6% of kidney cancer survivors) to 17 years (28% of brain and bone marrow survivors)
Most late effects are caused by chemotherapy or radiation that also damage the healthy cells
Cancers of the young are more aggressive and progress more rapidly than cancers seen in older adults
Today’s cancer treatments for our kids include blends of several adult drugs, referred to by some as the “kitchen sink” solution
Today's Diagnosis and Treatment
”There is no defined protocol for
diagnosing childhood cancer, so pathologists vary in levels of rigor in
the testing they undertake. In cases in which they are less aggressive,
there’s greater likelihood of misdiagnosis. There is no personalization
of treatment approaches. Few therapies are tailored to them. Children
are often treated with much higher doses of drugs that are designed for
adults. They are extremely toxic. The result? Treatment is usually
performed through trial and error leading to unnecessary pain and
suffering because the treatment for each cancer is so different.”
Childhood, adolescent and young adult cancers as a category are all considered rare diseases ( a condition affecting <200,000) providing little economic motivation for investments and development. Commercial research and development laboratories cannot justify the taking on rare cancers because they do not make economic sense. Thus, Investment capital is channeled to larger markets. Needed diagnostic and treatment solutions for children, adolescents and young adults are not reaching the clinic. Solutions for solving rare diseases require a different model.
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The Solution is TACTiC™
The Accelerator of Cancer Treatments in Children (TACTiC™)
is the business model by which TNCI operates. The Institute manages a
partnership of companies and a portfolio of translation initiatives.
Each company partner possesses highly skilled scientific, clinical and
business personnel, infrastructure, facilities and vital data.
Using TACTiC™, The Nicholas Conor Institute . . .
Deploys best in class organizations based on project need
Develops partnerships among research organizations, diagnostics and pharmaceutical companies, and clinical institutions
Manages a portfolio of research and discovery projects
Manages a broad database of scientific results for use in broader collaborations in both the academic and commercial sectors
"Children have usually been considered just small adults in the
medical profession. As a consequence, sick children, especially those
suffering from catastrophic illnesses like cancer, have had to endure
harsh treatments that have ravaged their developing bodies. The
Nicholas Conor Institute intends to focus on diagnostics and treatments
designed specifically for each child that will allow them to grow
normally and lead a happier life – that is why I have joined this
-Robert M. Cohn, MPH
THE NICHOLAS CONOR INSTITUTE 3525 Del Mar Heights Road, #946•San Diego, California 92130
Content Copyright 2015. The Nicholas Conor Institute. All rights reserved.